10 Best Profitable Businesses To Start in 2021 March 4, 2021 Professor Nez 10 Best Businesses To Start in 2021. This is the best time to start a new business and I share the best business ideas you can start in 2021 step by step. I know you can start a great business in 2021 and I hope these business ideas inspire you! I am living proof that with a lot of hard work and dedication any one of you can start a successful business in 2021. Let me know in the comments which business idea inspired you the most. I respond to all the comments personally and would love to hear from you!